Q: 腫瘍マーカー癌検診では、どうして超早期･超々早期で見つかるのですか？

投稿日時: 投稿者:

A: とても優れた質問ですね！！

実は、腫瘍マーカーは、殆どが蛋白質です｡　例えば　CEA　carcinoembryonic antigen　も下記のようなアミノ線の配列を持った蛋白質です｡

MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLL
IQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDA
VAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK
CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA
QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYA
EPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVIIRSLPVSPRLQLSND
NRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYR
PGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNS
ASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWW
VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD
VLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLLI
AKIQPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATAGIMIGVL
VGVALI

腫瘍マーカーの遺伝子を発現 ”する” か ”しない” か、は、癌細胞が発現のスイッチを ON にしているか、OFFにしているかで、決まります｡　それ故、消化器癌等の場合は、超々早期で、ONの場合は、超早期でもON、早期でもON、初期でもON、中期でもON、末期でもONと成ります｡　外からひとが『早期癌に成ったらONするようにしなさい！』と言ったからONにする訳でわありません｡

このようなメカニズムが判っていますと、感度を上げて、殆どブレが無ければ、超早期、超々早期でも癌が居るなと推理出来る訳です｡

日本には、世界に先駆けて、最先端の技術がありますので、超早期、超々早期で見つけ出し、得意の基本免疫で先ずやっつけ、囲い込みでやっつけ、血栓塞栓療法でやっつける事が出来ることになります｡

正常値の上限を100としますと、0～39: 真の正常値、40～59: グレーゾーン

 

 

 

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